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KMID : 0380619940260020188
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Korean Journal of Food Science and Technology
1994 Volume.26 No. 2 p.188 ~ p.194
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Inhibitory Effect of Rice Extract on the Chemically Induced Mutagenesis
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김인호/Kim, In Ho
김영진/김길환/전향숙/Kim, Young Jin/Kim, Kil Hwan/Chun, Hyang Sook
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Abstract
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The inhibitory effects of rice extract on mutagenicity induced by 3-amino-l,4-dimethyl-SH-pyrido [4,3-b]indole(Trp-P-1), 3-amino-l-methyl-SH-pyrido [4,3-b]indole(Trp-P-2), sodium azide(SA), 2-nitrofluorene(2NF), mitomycin C(MMC), aflatoxin B₁(AFB₁) and 4-nitroquinoline oxide(4-NQO) were investigated using Salmonella typhimurium reversion assay, SOS chromotest and spore rec-assay. In Salmonella typhimurium reversion assay, methanol extract from brown rice (Illpumbyeo, Japonica variety) showed the highest inhibitory effect among other extracting solvent including hexane, chloroform and water. Methanol extract showed stronger inhibitory effect, above 85%, on indirect-acting mutagens(TrpP-1, Trp-P-2 and AFB₁) than those on direct-acting mutagens(4-NQO, 2NF). In SOS chromotest, methanol extracts showed 77.6-88.9% e ´fects on SOS function induced by Trp-P-1, Trp-P-2, AFB, and 4-NQO. In spore rec-assay, methanol extracts inhibited the mutagenicity induced by AFB₁ and MMC. As the concentration of methanol extract increased, inhibitory effect on mutagenicity increased but reached at steady state as inhibition rate of 90% when the concentration was above 5 mg/plate. In inhibitory effects of methanol extracts by various rice varieties, all of 11 varieties turned out to have inhibitory effect on mutagenicity. There was no significant difference (p$gt;0.05) in inhibitory effect of methanol extracts between brown and white rice against Trp-P-1, but showed difference (p$lt;0.05) against 4-NQO.
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